Natarajan V. Bhanu

This study identifies NNMT as a tumor suppressor in prostate cancer that regulates SAM availability, mTORC1 signaling, and chromatin methylation, revealing a therapeutic strategy using dietary methionine restriction and mTORC1 inhibition.

This study shows that H3K27me3 maintenance in mature neurons via EZH1 has minimal impact on gene expression and chromatin accessibility.

The paper identifies H3K27me3's dual role in regulating transposons and cell type-specific genes in choanoflagellates, suggesting ancestral chromatin mechanisms in development.

This study shows YY1 enhances p300 acetyltransferase activity in CRPC, promoting histone acetylation and oncogenic gene expression, and identifies a potential therapeutic target for overcoming drug resistance.

This study shows that single nucleosomes encode A/B compartment information through biophysical properties, specifically condensability, which correlates with gene expression and is electrostatic in nature.

This study shows that PDGF-BB overexpression in p53 null OPCs increases H3K27me3 and promotes proliferation by altering transcription.

This study identifies epididymal glucocorticoid receptors as mediators of paternal stress effects on offspring through changes in extracellular vesicle miRs.