Nathan Wang

STRAIGHT-IN Dual: a platform for dual, single-copyintegrations of DNA payloads and gene circuits into human induced pluripotent stem cells

STRAIGHT-IN Dual enables efficient, single-copy integration of two DNA payloads into hiPSCs, improving genetic engineering for synthetic biology applications.

Programmable nanobody circuits for cell selection

This paper introduces DASIT, a protein-based circuit for antigen-specific cell selection, demonstrating its utility in genome engineering, CRISPR screening, and cell therapy manufacturing.

Cells transit through a quiescent-like state to convert to neurons at high rates

The paper identifies a quiescent-like state with reduced nuclear size and transcriptional activity that enables efficient TF-mediated conversion of fibroblasts to neurons.