Author

Karl M Gogan

Trinity College DublinORCID 0000-0002-9570-8671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Aenea AI BrugmaniD· 1 shared Cilian Ó MaoldomhnaighiD· 1 shared Dearbhla M MurphyiD· 1 shared Donal J CoxiD· 1 shared Emily DuffiniD· 1 shared Finbarr O’ConnelliD· 1 shared James Joseph PhelaniD· 1 shared Joseph KeaneiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Aenea AI BrugmanORCID

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1 paper

Recent·Most cited

Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis dependent functional plasticity.

Donal J Cox, Sarah A Connolly, Cilian Ó Maoldomhnaigh, Aenea AI Brugman, Olivia Sandby Thomas, Emily Duffin, Karl M Gogan, Oisin Ó Gallchobhair, Dearbhla M Murphy, Sinead A O’Rourke, Finbarr O’Connell, Parthiban Nadarajan, James Joseph Phelan, Laura E. Gleeson, Sharee A. Basdeo, Joseph Keane

This study shows that human airway macrophages reprogram their metabolism in response to IFN-γ, leading to glycolysis-dependent functional plasticity that differs from monocyte-derived macrophages.

eLife · Jun 20, 2024Peer-reviewedImmunology