Guillermo E. Parada

Mining alternative splicing patterns in scRNA-seq data using scASfind

scASfind identifies cell type-specific alternative splicing patterns in scRNA-seq data, revealing splicing events missed by gene-level analysis.

Alternative splicing modulation by G-quadruplexes

The paper identifies G-quadruplex motifs enriched near splice junctions and shows their involvement in alternative splicing in neuronal cells.

Droplet-based Single-cell Total RNA-seq Reveals Differential Non-Coding Expression and Splicing Patterns during Mouse Development

The paper introduces VASA-seq, a method for total single-cell RNA-seq in mice, revealing non-coding RNA expression and alternative splicing during development.

Single paternal Dexamethasone challenge programs offspring metabolism and reveals circRNAs as novel candidates in RNA-mediated inheritance

The paper shows acute paternal Dexamethasone exposure alters sperm RNA and offspring metabolism, identifying circRNAs as novel RNA-mediated inheritance candidates.

MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development

MicroExonator identifies and quantifies microexons across mouse embryonic development, revealing 332 differentially spliced microexons and cell-type specific inclusion in neuronal subpopulations.

The Aquarius/EMB-4 helicase licenses co-transcriptional gene silencing

This study identifies the Aquarius/EMB-4 helicase as essential for initiating small RNA-induced co-transcriptional gene silencing in C. elegans by facilitating HRDE-1 complex engagement with nascent transcripts.