Author

Sebastian B. Jørgensen

Novo Nordisk (Denmark)ORCID 0000-0002-9648-0971Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alan C. RuppiD· 1 shared Amalie Rasmussen LanngiD· 1 shared Anita R. PateliD· 1 shared Cecilie Bæch‐LaurseniD· 1 shared David P. OlsoniD· 1 shared Desiree GordianiD· 1 shared Emilie S. AnderseniD· 1 shared Filip Krag KnopiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Alan C. RuppORCID

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Author profile →

2 papers

Recent·Most cited

A loss-of-function variant in GFRAL associates with increased alcohol consumption in humans

Johanne Marie Justesen, Kimmie V. Sørensen, Jayashri Seshadri, Jens Skjoldan Svenningsen, Matthew Aguirre, Yosuke Tanigawa, Robert Minneker, Amalie Rasmussen Lanng, Cecilie Bæch‐Laursen, Emilie S. Andersen, Louise Julie Skov, Sebastian B. Jørgensen, Ulrik Becker, Filip Krag Knop, Manuel A. Rivas, , Matthew Paul Gillum

The paper identifies a loss-of-function variant in GFRAL associated with increased alcohol consumption in humans and shows GDF15 reduces alcohol drinking in mice.

bioRxiv · Mar 9, 2026 · PreprintPhysiology

Gfral-expressing Neurons Suppress Food Intake via Aversive Pathways

Paul V. Sabatini, Henriette Frikke‐Schmidt, Joe Arthurs, Desiree Gordian, Anita R. Patel, Alan C. Rupp, Jessica M. Adams, Jine Wang, Sebastian B. Jørgensen, David P. Olson, Richard D. Palmiter, Martin Grosvenor Myers, Randy J. Seeley

This study identifies GFRAL-expressing neurons in the hindbrain that suppress food intake through aversive pathways by responding to non-meal-related signals.

Proceedings of the National Academy of Sciences · Feb 15, 2021Peer-reviewedNeuroscience