Randy J. Seeley

This study identifies a single dorsal vagal complex circuit that mediates both aversive and anorectic responses to GLP1R agonists, showing that APGlp1r neurons are responsible for both effects.

This study identifies rapid remodeling of human subcutaneous white adipose tissue within one month after bariatric surgery using snRNA-seq, revealing changes in adipocyte populations and transcriptional dynamics.

The paper identifies a neural pathway from the gut to the pancreas that enhances insulin secretion and glucose tolerance by modulating beta cell function.

The paper identifies GFRAL expression in the caudal brainstem and shows minimal expression in peripheral tissues in mice and humans.

The paper identifies mediators of improved glycemia after gastric bypass surgery using a high-throughput mediation analysis method applied to plasma proteome and metabolome data.

This study identifies GFRAL-expressing neurons in the hindbrain that suppress food intake through aversive pathways by responding to non-meal-related signals.