In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
Beata Turoňová, Mateusz Sikora, Christoph Schürmann, Wim J. H. Hagen, Sonja Welsch, Florian E.C. Blanc, Sören von Bülow, Michael Gecht, Katrin Bagola, Cindy Hörner, Ger van Zandbergen, Jonathan J. M. Landry, Nayara Trevisan Doimo de Azevedo, Shyamal Mosalaganti, Andre Schwarz, , Martin Beck
This study uses cryo electron tomography and simulations to analyze the structure of SARS-CoV-2 spike protein in situ, revealing three hinges in the stalk domain that enable orientational flexibility.
Science · Aug 18, 2020Peer-reviewedMolecular Biology