Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail
Joseph Atherton, Magda S. Chegkazi, Marco Leusciatti, Michele Di Palma, Elisa Peirano, Lisa Sofia Pozzer, Massimiliano Meli, Sebastiano Pasqualato, T Foran, Giulia Morra, Roberto A. Steiner
This study uses cryo-EM to reveal how microtubule association induces an Mg-free apo-like ADP pre-release conformation in kinesin-1, independent of tail interactions.
Nature Communications · Jul 5, 2025Peer-reviewedBiochemistry