Christian D. Klose

The paper shows that chronic hyperosmotic stress in budding yeast leads to lipid droplet accumulation and membrane remodelling, which are essential for cell fitness.

This study compares lipidomes of five yeast strains, finding significant differences in lipid classes and molecular species, with transcriptomic data suggesting post-transcriptional regulation.

C-COMPASS predicts protein and lipid localization across cellular compartments using neural networks, enabling multi-omic analysis of organelle dynamics in humanized liver mice.

This study identifies 495 genetic associations with plasma lipid species using genome-wide analysis in 7,174 Finnish individuals and fine-mapping in 377,277 participants, revealing 9 novel loci and disease links.

The paper examines sex differences in circulatory lipids and their genetic determinants using lipidomics and genome-wide association studies across multiple cohorts.

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

The paper conducts GWAS and PheWAS on plasma lipid species to identify genetic associations and their links to diseases beyond traditional lipid measures.