Lgr5+ intestinal stem cells are required for organoid survival after genotoxic injury
Joseph Lee, Antoine R. Gleizes, Nicolas V. Janto, Lito L. Appell, Siyang Sun, Felipe Takaesu, Sarah F. Webster, Taylor Hailstock, Nick Barker, Adam D. Gracz
This study shows that Lgr5+ intestinal stem cells are necessary for organoid survival after genotoxic injury, despite fISC gene activation occurring at both low and high doses of doxorubicin.
Development · Nov 6, 2024Peer-reviewedCell Biology