Author

Nick Barker

Agency for Science, Technology and ResearchORCID 0000-0003-3566-4475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adam D. GracziD· 1 shared Alexander M. TsankoviD· 1 shared Antoine R. GleizesiD· 1 shared Bruno GiottiiD· 1 shared Dan HassoniD· 1 shared Daniel Lozano‐OjalvoiD· 1 shared Denis TorreiD· 1 shared Deniz DemircioğluiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCell Biology

Adam D. GraczORCID

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2 papers

Recent·Most cited

Cancer BiologyNature GeneticsPeer-reviewedFeb 1, 2025

A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer

Slim Mzoughi, Megan Catherine Schwarz, Xuedi Wang…·Ernesto Guccione

This study identifies an oncofetal cell state that contributes to resistance in colorectal cancer and shows that targeting both this state and LGR5+ CSCs is needed for effective treatment.

97 citationstop 1%

humanbulk RNA-seq

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Cell BiologyDevelopmentPeer-reviewedNov 6, 2024

Lgr5+ intestinal stem cells are required for organoid survival after genotoxic injury

Joseph Lee, Antoine R. Gleizes, Nicolas V. Janto…·Adam D. Gracz

This study shows that Lgr5+ intestinal stem cells are necessary for organoid survival after genotoxic injury, despite fISC gene activation occurring at both low and high doses of doxorubicin.

6 citations

mouseorganoid / primary culture

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