Anoop P. Patel

This study shows that IL-12-secreting CAR-T cells improve glioblastoma treatment by enhancing T-cell persistence and reprogramming the tumor microenvironment without lymphodepletion.

The paper examines HCN-channel properties in primate supragranular pyramidal neurons, finding conserved traits across species with some divergence in magnitude between humans and macaques.

This study characterizes quiescent subpopulations and proliferative compartments in glioblastoma, finding that quiescent cells continuously cycle and lack stable dormant states.

This study assesses how pre-analytical variables affect DNA methylation analysis of the MGMT promoter in gliomas, finding that most variations do not significantly impact results but intratumor heterogeneity is prevalent.

The paper shows how gene regulatory network topology in glioma stem-like cells influences drug resistance and treatment escape, suggesting strategies to overcome resistance through combinatorial therapies.

The paper introduces ccAFv2, a high-resolution cell cycle classifier for scRNA-seq data, which outperforms existing methods and classifies six cell cycle states and a quiescent-like G0 state.

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

The paper uses single-cell analysis of GBM patient samples and xenografts to identify regulatory networks driving treatment-induced tumor evolution and proposes a framework for precision medicine.

The paper identifies conserved and divergent morpho-electric and transcriptomic properties of human and rodent layer 5 extratelencephalic-projecting neurons using patch-seq in human brain slices.

This paper develops scCUT&Tag to profile H3K27me3 in single cells, distinguishing cell types in blood and identifying PcG activity changes in brain tumors before and after treatment.