David Shore

The paper shows that Not1 and Not4 oppositely regulate mRNA solubility, affecting co-translational dynamics in yeast.

The paper addresses concerns about ChEC-seq's ability to distinguish signal from noise by demonstrating normalization methods and validating its reliability through functional assays.

This study identifies two complementary mechanisms for regulating ribosomal protein gene transcription in yeast under stress, involving Ifh1 and Sfp1, and reveals an unexpected role for Hmo1 in protein homeostasis.

The paper shows that the Tof1-Csm3 complex recruits topoisomerase I to the replisome to promote fork pausing at replication fork barriers, independent of Rrm3 helicase.

The paper investigates how opposing chromatin remodelers influence transcription initiation frequency and start site selection in budding yeast by analyzing their binding and nucleosome displacement activity.

The paper shows that ribosome assembly stress triggers a pathway that balances Hsf1 and Ifh1 activity to prevent proteotoxic stress in yeast.

This study shows that General Regulatory Factors like Rap1 suppress ectopic transcription initiation and maintain nucleosome positioning, ensuring transcription fidelity in yeast.

This study identifies Sfp1 as a master regulator of cell growth and division in yeast by coordinating gene expression through two distinct promoter binding modes.

The paper shows that RSC remodeler and pioneer factors work independently to position the +1 nucleosome at yeast promoters, facilitating transcription initiation through DNA sequence-directed action.