Author

Xiaokang Wang

Children's Hospital of PhiladelphiaORCID 0000-0002-9850-9248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genomics· 1

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Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 1

Frequent Co-Authors

Belinda M. GiardineiD· 2 shared Cheryl A. KelleriD· 2 shared Gerd A. BlobeliD· 2 shared Jessica C. LamiD· 2 shared Nicholas G. AboredeniD· 2 shared Ross C. HardisoniD· 2 shared Alma Quijano· 1 shared Anders S. HanseniD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenomics

Belinda M. GiardineORCID

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3 papers

Recent·Most cited

Single-stranded DNA binding proteins are essential components of the architectural LDB1 protein complex

Xiaokang Wang, Nicholas G. Aboreden, Ying Cai, Jessica C. Lam, Kate A. Henderson, Jiaqi Xiang, Belinda M. Giardine, Ross C. Hardison, Cheryl A. Keller, Lalitha Nagarajan, Stephen J. Brandt, Gerd A. Blobel

This study shows SSBP3 is essential for LDB1-mediated chromatin looping and transcription, and stabilizes LDB1 homodimers.

Molecular Cell · Aug 1, 2025Peer-reviewedGenomics

LDB1 establishes multi-enhancer networks to regulate gene expression

Nicholas G. Aboreden, Jessica C. Lam, Viraat Y. Goel, Siqing Wang, Xiaokang Wang, Susannah C. Midla, Alma Quijano, Cheryl A. Keller, Belinda M. Giardine, Ross C. Hardison, Haoyue Zhang, Anders S. Hansen, Gerd A. Blobel

This study shows LDB1 directly promotes enhancer-promoter loops and organizes multi-enhancer networks to activate transcription, independent of CTCF, cohesin, or YY1.

Molecular Cell · Dec 24, 2024Peer-reviewedMolecular Biology

The MLL3/4 complexes and MiDAC act antagonistically as genome-wide regulators of H4K20ac to control a specific gene expression program

Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Baisakhi Mondal, Satish Kallappagoudar, Andrey Tvardovskiy, Richa Bajpai, Beisi Xu, Shondra M. Pruett‐Miller, Robert Schneider, Hans‐Martin Herz

The paper shows that MiDAC and MLL3/4 complexes antagonistically regulate H4K20ac and gene expression through their interaction and co-localization at enhancer regions.

bioRxiv · Dec 17, 2021 · PreprintMolecular Biology