Author

Sophie Hélaine

Harvard UniversityORCID 0000-0002-9877-4180Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Matthew J. G. EldridgeiD· 2 shared Antoine‐Emmanuel SalibaiD· 1 shared Bastian Klodewig· 1 shared Benjamin I. Morris· 1 shared Brian P. ConloniD· 1 shared Brian P. HardyiD· 1 shared Christophe ToussaintiD· 1 shared Fabian Joachim TheisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Matthew J. G. EldridgeORCID

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2 papers

Recent·Most cited

Multimodal temporal mapping of macrophage transcriptome remodeling during Salmonella infection

Christophe Toussaint, Peter W. S. Hill, Bastian Klodewig, Matthew J. G. Eldridge, Fabian Joachim Theis, Sophie Hélaine, Antoine‐Emmanuel Saliba

The paper uses temporal single-cell RNA-seq and other methods to study how Salmonella rewires macrophage gene expression and transcription factor activity during infection.

bioRxiv · Jul 6, 2026 · PreprintGenomics

A host-directed adjuvant resuscitates and sensitizes intracellular bacterial persisters to antibiotics

Kuan‐Yi Lu, Xiangbo Yang, Matthew J. G. Eldridge, Rongfeng Sun, Rachel T. Giorgio, Benjamin I. Morris, Nikki J. Wagner, Brian P. Hardy, Matthew Axtman, Sarah E. Rowe, Xiaodong Wang, Vance G. Fowler, Qingyun Liu, Sophie Hélaine, Kenneth H. Pearce, Brian P. Conlon

This study identifies a host-directed adjuvant, KL1, that increases intracellular bacterial energy and sensitizes persisters to antibiotics by modulating host immune responses and reducing reactive species production.

Nature Microbiology · Oct 10, 2025Peer-reviewedMicrobiology