Author

Charlotta G. Lebedenko

Boston Children's HospitalORCID 0000-0002-9891-9247Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Peiyuan ChaiiD· 4 shared Ryan A. FlynniD· 4 shared Helena HembergeriD· 3 shared Benson M. GeorgeiD· 2 shared Christopher P. WatkinsiD· 2 shared Jennifer PoratiD· 2 shared Jonathan PerriD· 2 shared Reese M. CaldwelliD· 2 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMolecular Biology

Peiyuan ChaiORCID

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Author profile →

4 papers

Recent·Most cited

O-glycosylation contributes to mammalian glycoRNA biogenesis

Jennifer Porat, Christopher P. Watkins, Chunsheng Jin, Xixuan Xie, Xiao Tan, Charlotta G. Lebedenko, Helena Hemberger, Woojung Shin, Peiyuan Chai, James J. Collins, Benjamin Aaron Garcia, Daniel Bojar, Ryan A. Flynn

This study demonstrates that O-glycosylation contributes to sialoglycoRNA biogenesis and shows increased sialylation in ulcerative colitis-derived organoids.

bioRxiv · Aug 28, 2024 · PreprintMolecular Biology

The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA

Yixuan Xie, Peiyuan Chai, Nicholas A. Till, Helena Hemberger, Charlotta G. Lebedenko, Jennifer Porat, Christopher P. Watkins, Reese M. Caldwell, Benson M. George, Jonathan Perr, Carolyn Ruth Bertozzi, Benjamin A. Garcia, Ryan A. Flynn

The paper identifies acp3U as the site where N-glycans attach to RNA in glycoRNA using rPAL and SWATH-MS.

Cell · Aug 22, 2024Peer-reviewedMolecular Biology

Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

Peiyuan Chai, Jonathan Perr, Lauren Kageler, Charlotta G. Lebedenko, João M.L. Dias, Eliza Yankova, Jeffrey D. Esko, Konstantinos Tzelepis, Ryan A. Flynn

The paper identifies heparan sulfate proteoglycans as key organizers of cell surface glycoRNA and RNA binding proteins, showing their role in regulating growth factor signaling.

bioRxiv · Jul 25, 2024 · PreprintMolecular Biology

Rapid and sensitive detection of native glycoRNAs

Helena Hemberger, Peiyuan Chai, Charlotta G. Lebedenko, Reese M. Caldwell, Benson M. George, Ryan A. Flynn

This paper introduces rPAL, a method for detecting native sialoglycoRNAs with significantly improved sensitivity compared to existing methods, demonstrating its application in human clinical samples.

bioRxiv · Feb 26, 2023 · PreprintMolecular Biology