Jeffrey D. Esko

This paper introduces HS-nano-seq, a method to analyze heparan sulfate using nanopore sequencing, enabling single-molecule detection of sulfation patterns and structural features.

This study measures sulfated glycosaminoglycan (sGAG) levels in ventricular CSF, blood, and urine of TBI patients to assess extracellular matrix damage and its correlation with injury characteristics.

The paper analyzes the BBB glycocalyx using multi-omic approaches, revealing unique glycan composition and structural features, and their potential role in neuroinflammation.

The paper identifies heparan sulfate proteoglycans as key organizers of cell surface glycoRNA and RNA binding proteins, showing their role in regulating growth factor signaling.

This study identifies critical human host factors involved in SARS-CoV-2 multicycle replication through a genome-scale siRNA screen and validates potential antiviral targets.

This study shows that chondroitin sulfates and heparan sulfates play distinct roles in the assembly and barrier function of the retinal basement membrane.

PinAPL-Py provides a user-friendly web application for analyzing CRISPR/Cas9 screening data, offering comprehensive tools and workflows for sequence analysis and gene ranking.