Peiyuan Chai

4D force patterning enables spatial control of angiogenesis

This paper demonstrates that 4D force patterning using a magnetically actuated vessel-on-a-chip platform enables precise spatiotemporal control over angiogenesis by modulating mechanical strain magnitude, frequency, and direction.

O-glycosylation contributes to mammalian glycoRNA biogenesis

This study demonstrates that O-glycosylation contributes to sialoglycoRNA biogenesis and shows increased sialylation in ulcerative colitis-derived organoids.

The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA

The paper identifies acp3U as the site where N-glycans attach to RNA in glycoRNA using rPAL and SWATH-MS.

Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

The paper identifies heparan sulfate proteoglycans as key organizers of cell surface glycoRNA and RNA binding proteins, showing their role in regulating growth factor signaling.

Rapid and sensitive detection of native glycoRNAs

This paper introduces rPAL, a method for detecting native sialoglycoRNAs with significantly improved sensitivity compared to existing methods, demonstrating its application in human clinical samples.