Xi Yang

Alpha Spatial: Language-guided prediction of single-cell spatial gene expression from histology

Alpha Spatial predicts single-cell gene expression from histology using language-guided models, improving accuracy with matched biological context and outperforming existing methods in breast cancer analysis.

High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae

This paper introduces a high-throughput 24-camera array microscope for automated 3D behavioral analysis of zebrafish larvae, enabling accurate tracking and morphological dynamics at high frame rates.

Impact of blood storage conditions on the transcript profile of plasma cell-free RNA

This study evaluates how blood storage conditions affect plasma cell-free RNA transcript profiles, finding that mRNA and lncRNA stability is highest at 4°C for 6 hours or RT for 2 hours.

Evaluation of five cell-free DNA isolation kits for plasma

The paper evaluates five cfDNA isolation kits for plasma, finding that all can isolate cfDNA with varying efficiency, with VZ kit achieving 90% efficiency comparable to QC.

Assessment of the gene expression profiles of leukocytes from different isolations

This study compares gene expression profiles of leukocytes from different isolation methods, finding that RBC lysis reduces globin mRNA and improves transcriptome quality.

Acidic microenvironment shaped by lactate accumulation promotes pluripotency through multiple mechanisms

This study shows that an acidic microenvironment, caused by lactate accumulation, promotes pluripotency in mouse and human ESCs through multiple mechanisms involving histone modification, mRNA stability, and microRNA regulation.