This study shows that viscoelasticity of substrates affects fibroblast adhesion, migration, and YAP activity, suggesting its importance in fibrotic disease modeling.

Biointerphases · Jul 1, 2025Peer-reviewedBioengineering

Size-dependent secondary nucleation and amplification of α-synuclein amyloid fibrils

Arunima Sakunthala, Debalina Datta, Ambuja Navalkar, Laxmikant G. Gadhe, Pradeep Kadu, Komal Patel, Surabhi Mehra, Rakesh Kumar, Debdeep Chatterjee, Kundan Sengupta, Ranjith Padinhateeri, Samir Kumar Maji

This study investigates how the size of α-synuclein fibril seeds affects their amplification, cellular uptake, and toxicity, revealing distinct mechanisms for small and large seeds.

bioRxiv · Dec 28, 2021 · PreprintNeuroscience

A novel cis regulatory element regulates human XIST in CTCF-dependent manner

Rini Shah, Ankita Sharma, Ashwin Kelkar, Kundan Sengupta, Sanjeev Galande

The paper identifies a novel cis regulatory element in human XIST that is regulated by CTCF and YY1 during X chromosome inactivation.

Molecular and Cellular Biology · Jun 1, 2021Peer-reviewedGenomics

Nup93 and CTCF co-modulate spatiotemporal dynamics and function of the HOXA gene cluster during differentiation

Ajay S. Labade, Adwait Salvi, Krishanpal Karmodiya, Kundan Sengupta

This study shows Nup93 and CTCF regulate HOXA gene dynamics during differentiation by modulating chromatin organization and gene expression.

bioRxiv · Jul 2, 2019 · PreprintMolecular Biology