Author

Ronald J. Biggs

Northwestern UniversityORCID 0000-0002-9965-6346Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:experimental assay· 4 Organism:C. elegans· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

John F. MarkoiD· 2 shared Shirin BahmanyariD· 2 shared Aaron F. StraightiD· 1 shared Brian WysolmerskiiD· 1 shared Curtis Broberg· 1 shared Daniel J. NeedlemaniD· 1 shared Eline HendrixiD· 1 shared Frances E. Q. MooreiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersGenomics

John F. MarkoORCID

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4 papers

Recent·Most cited

TMEM209/NPP-28 partitions PLK-1 between the nuclear envelope and nuclear interior during mitosis

Victoria Puccini de Castro, Sarah R. Barger, Răzvan Azamfirei, Tiffany Y Su, Rebecca A. Green, Ronald J. Biggs, Frances E. Q. Moore, Shoken Lee, Karen Oegema, Pablo Lara-González, Shirin Bahmanyar

This study identifies NPP-28 as a regulator of PLK-1 localization during mitosis, showing it partitions PLK-1 between the nuclear envelope and interior to control NEBD.

bioRxiv · Oct 6, 2026 · PreprintCell Biology

Mitotic chromosomes are mechanically connected by chromatin-based interchromosome linkers

John F. Marko, Ronald J. Biggs, Omar Akhtar, Gabriel Quintero Plancarte, Lisa L. Hua

The paper demonstrates that mitotic chromosomes are mechanically connected by DNA-based interchromosome linkers, identified through micropipette manipulation and enzymatic treatments.

bioRxiv · Sep 4, 2026 · PreprintGenomics

Independence of centromeric and pericentromeric chromatin stability on CCAN components

Ronald J. Biggs, Mingxuan Sun, Kousik Sundararajan, Eline Hendrix, Aaron F. Straight, John F. Marko

This study shows that centromeric chromatin is mechanically resilient and distinct from pericentromeric chromatin, which deforms under force, with CCAN components not affecting pericentromere stretching.

Molecular Biology of the Cell · Feb 12, 2025Peer-reviewedCell Biology

Dynein Pulling Forces On Ruptured Nuclei Counteract Lamin-Mediated Nuclear Envelope Repair Mechanisms In Vivo

Lauren Penfield, Brian Wysolmerski, Michael Sean Mauro, Reza Farhadifar, Michael A. Q. Martinez, Ronald J. Biggs, Hai‐Yin Wu, Curtis Broberg, Daniel J. Needleman, Shirin Bahmanyar

This study shows that dynein forces on ruptured nuclei counteract lamin-mediated nuclear envelope repair in C. elegans embryos, affecting NE rupture duration and recovery.

Molecular Biology of the Cell · Jan 31, 2018Peer-reviewedCell Biology