Pablo Lara-González

This study identifies NPP-28 as a regulator of PLK-1 localization during mitosis, showing it partitions PLK-1 between the nuclear envelope and interior to control NEBD.

This study shows cyclin B3-CDK1/2 drives mitotic progression and fidelity in cancer cells, with overexpression accelerating mitosis and depletion disrupting it in multiple cancer models.

This study shows that cyclin B3-CDK1 promotes mRNA de-repression in C. elegans embryos by degrading OMA proteins, linking mitosis to early gene expression.

This study shows mammalian cells use ER and NE structure to control mitotic timing, with ER stress delaying mitosis and disrupting spindle formation.

This study shows that the CYK-4 GAP domain recruits centralspindlin to the equatorial cortex and its catalytic activity facilitates ring dissolution during cytokinesis.

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

The paper describes a method for tissue-specific protein degradation in C. elegans using a GFP-targeting nanobody fused to a ubiquitin ligase adaptor, enabling efficient ablation of GFP-tagged proteins in multiple tissues.