Daniel J. Needleman

This study uses control theory to analyze dynamic metabolic responses in mouse oocytes, revealing cytoplasmic NADH flux overshoot due to mitochondrial-cytoplasmic coupling and nutrient partitioning.

The paper shows that microtubule asters in C. elegans use a cellular analog of geometric optics to position pronuclei during cell division, with surface-anchored motors and dynamic terminator curves governing this process.

This study develops a model to analyze how error correction and the spindle assembly checkpoint affect mitotic timing and fidelity in human cells.

This study develops a quantitative framework to distinguish between clock and domino mechanisms in embryogenesis, finding domino governs cleavage timings while a clock mechanism governs morula and blastocyst timings.

The paper introduces cryoJAX, a cryo-EM image simulation library built on JAX for developing data analysis techniques in cryo-EM.

The paper quantifies mitotic spindle and chromosome segregation dynamics in C. elegans embryos, finding that spindle elongation scales with cell size while chromosome segregation remains invariant.

The paper explains aerobic glycolysis as a result of mitochondrial respiration saturation and decoupling of mitochondrial biogenesis from other cellular processes.

The paper quantifies mitotic error correction dynamics in human cells and validates a model explaining error reduction and anaphase timing.

This study shows that dynein forces on ruptured nuclei counteract lamin-mediated nuclear envelope repair in C. elegans embryos, affecting NE rupture duration and recovery.