Reza Farhadifar

This study shows that the Wnt co-receptor Arrow-LRP5/6 is essential for Planar Cell Polarity (PCP) establishment in Drosophila, correcting the previous notion that PCP signaling operates without co-receptors.

The paper shows that microtubule asters in C. elegans use a cellular analog of geometric optics to position pronuclei during cell division, with surface-anchored motors and dynamic terminator curves governing this process.

The paper quantifies mitotic spindle and chromosome segregation dynamics in C. elegans embryos, finding that spindle elongation scales with cell size while chromosome segregation remains invariant.

This paper develops a first-principles geometric model to study motor-driven centrosomal aster dynamics, showing how cell shape and motor number affect aster stability and revealing new nonlinear phenomena.

This study shows that dynein forces on ruptured nuclei counteract lamin-mediated nuclear envelope repair in C. elegans embryos, affecting NE rupture duration and recovery.