Karen Oegema

The paper develops a tissue-targeted auxin-inducible degradation toolkit for C. elegans embryogenesis and shows that LET-502 degradation in the epidermis disrupts elongation, with unexpected roles in both early and late stages.

This study identifies NPP-28 as a regulator of PLK-1 localization during mitosis, showing it partitions PLK-1 between the nuclear envelope and interior to control NEBD.

The paper shows phosphorylation remodels centrosome matrix proteins to create docking sites for gamma-tubulin complexes, enabling microtubule nucleation during mitosis.

This study identifies a chromatin-associated pool of Aurora A regulated by TPXL-1 that ensures proper chromosome biorientation by stabilizing kinetochore-microtubule attachments.

The paper shows Inhibitor-2 facilitates PP1 holoenzyme formation by transferring catalytic subunits to adapters via its RVxF docking motif, with mutations disrupting this process.

The paper identifies genes that activate the mitotic stopwatch by CRISPR/Cas9 screening, showing it synergizes with mild p53 activation to halt cell proliferation.

This study identifies how TRIM37 prevents ectopic spindle pole formation by recognizing peptide motifs in centrobin and undergoing substrate-dependent oligomerization.

This study shows that the CYK-4 GAP domain recruits centralspindlin to the equatorial cortex and its catalytic activity facilitates ring dissolution during cytokinesis.

This study identifies early developmental failures in hybrid Caenorhabditis embryos that lead to hybrid incompatibility.

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

The paper describes a method for tissue-specific protein degradation in C. elegans using a GFP-targeting nanobody fused to a ubiquitin ligase adaptor, enabling efficient ablation of GFP-tagged proteins in multiple tissues.