Joshua C Dent

Structure-Guided Design of C5aR1-Selective Peptide Agonists

This study designs C5aR1-selective peptide agonists using structure-guided computational methods and experimental validation, showing improved selectivity and stability through specific amino acid substitutions.

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors

This paper identifies naturally-encoded signaling bias at C5aR1 and C5aR2 receptors through structural and functional analyses, revealing molecular mechanisms underlying biased signaling in GPCRs.

Consumption of processed foods impairs memory function through dietary advanced glycation end-products

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.