Shih‐Jen Tsai

Trans-ancestry genome-wide association meta-analysis of antidepressant response to selective serotonin reuptake inhibitors in clinical studies of depression

This study performs a trans-ancestry GWAS of SSRI response in depression, finding suggestive associations and enrichment in serotonergic pathways but no genome-wide significant variants.

Meta-analysis of CYP2C19 and CYP2D6 metabolic activity on antidepressant response from 13 clinical studies using genotype imputation

This study examines the association between CYP2C19 and CYP2D6 metabolic phenotypes and antidepressant response using genotype imputation across 13 studies, finding no significant associations after correction for multiple testing.

Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference

This paper conducts a multi-ancestry GWAS of major depression, identifying 190 loci and 354 genes, with findings showing increased fine-mapping power and bidirectional BMI relationship in European ancestry samples.

Alteration of Power Law Scaling of Spontaneous Brain Activity in Schizophrenia

This study examines power law scaling in resting-state fMRI data from schizophrenia and healthy controls, finding significant differences in six brain regions linked to psychosis severity.

Differential patterns of gyral and sulcal morphological changes during normal aging process

This study examines age-related changes in gyral and sulcal morphology using MRI data from 417 participants, finding that sulcal thinning is more prominent than gyral changes during aging.

Topographic diversity of structural connectivity in schizophrenia

This study examines structural connectivity diversity in schizophrenia using DTI, finding reduced topographic diversity in patients compared to controls, suggesting a common pathway underlying the disease's heterogeneity.