Patrick H. O’Farrell

The paper shows that Brd4 acts as a mitotic bookmark to coordinate transcription and replication timing in Drosophila embryos, preventing collisions between replication forks and transcripts.

The paper investigates how cell cycle regulation controls transcriptional pausing of Drosophila replication-dependent histone genes, showing that Cyclin E/Cdk2 activation drives full-length transcript production during S phase.

The paper identifies age-dependent selection forces that drive mtDNA mutation accumulation in liver cells, leading to functional decline.

The paper shows that Eggless/SetDB1 is essential for heterochromatin formation in Drosophila embryos, with cell cycle speed regulating its accumulation.

This study shows Rif1 extends S phase during the Drosophila MBT by regulating replication timing and interacting with Cdc7.

The paper shows that Drosophila embryos can progress through developmental stages without a rise in nuclear-cytoplasmic ratio by arresting cell cycles, revealing a regulatory cascade linking cell-cycle slowing to transcriptional activation.

The paper shows that knocking down the mitochondrial DNA polymerase Tamas blocks paternal mtDNA loss in Drosophila, suggesting a novel role for DNA polymerase in mtDNA elimination.