Mapping DHPS Evolvability: Identification of Novel Evolutionarily Critical Sub-Structure through Evolutionary and Structural Analyses of DHPS
Dwipanjan Sanyal, Arti Shivram, Deeptanshu Pandey, Suharto Banerjee, Vladimir Nikolaevich Uversky, Danny Muzata, Aneesh Sreevallabh Chivukula, Ravi Jasuja, Krishnananda Chattopadhyay, Sourav Chowdhury
The paper identifies a critical substructure in DHPS through evolutionary and structural analyses, suggesting it as a target to constrain evolvability and disrupt antibiotic resistance.
International Journal of Biological Macromolecules · Apr 18, 2025Peer-reviewedBiophysics