Robert Lowe

This study develops epigenetic clocks for axolotls, revealing biphasic age prediction during early life but not later, and highlights methylome stability across lifespan.

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

The paper develops a method to generate locus-specific chromatin profiles at transposable elements using HiChIP and PAtChER, revealing epigenetic variation in young TEs in mouse and human cells.

The paper develops CellAgeClock, an epigenetic clock to measure ageing in human cells, identifies anti-ageing drugs, and validates their efficacy in vivo.

The paper integrates chromatin accessibility and DNA methylation data from human pancreatic islets to refine regulatory mechanisms at Type 2 Diabetes susceptibility loci.