Ryan P. Barnes

This study shows that inducing oxidative base damage at telomeres increases cancer cell sensitivity to ATR inhibition by causing genome instability and reduced viability.

This study shows DNA polymerase η is regulated by both mono-ubiquitination and mono-NEDDylation at the same lysine residues, with NEDDylation disrupting foci formation.

The paper shows that OGG1 and MUTYH repair activities are required for telomeric 8-oxoguanine-induced cellular senescence, with their loss reducing senescence and telomere dysfunction.

This study shows that telomeric 8-oxoguanine induces premature senescence without telomere shortening by causing replication stress and dysfunction.