Author

Nicholas William Ashton

Harvard UniversityORCID 0000-0002-9708-6319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alan D. D’AndreaiD· 2 shared Emilie J. KorchakiD· 2 shared Irina BezsonovaiD· 2 shared Shuhei AsadaiD· 2 shared Sirisha MukkavalliiD· 2 shared Dana A. D’OrlandoiD· 1 shared Divya IyeriD· 1 shared Dmitry M. KorzhneviD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Alan D. D’AndreaORCID

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3 papers

Recent·Most cited

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

Shuhei Asada, Guangli Zhu, Jithma P. Abeykoon, Yutaro Tanaka, Huy Nguyen, Yuna Hirohashi, Divya Iyer, Nicholas William Ashton, Sirisha Mukkavalli, Martha Velazquez, Lige Jiang, Miles D. Del Busso, Judith Jebastin Thangaiah, Steven Ian Robinson, Kalindi Parmar, , Alan D. D’Andrea

This paper shows that Ewing sarcoma cells have reduced POLθ expression and MMEJ activity due to EWS-FLI1 or EWSR1 disruption, making them sensitive to inhibitors of FA, NHEJ, or HR pathways.

Molecular Cell · Jul 21, 2026Peer-reviewedCancer Biology

USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality

Nicholas William Ashton, Ramya Ravindranathan, Emilie J. Korchak, Ozge Somuncu, Gabriella A. Zambrano, Sirisha Mukkavalli, Shuhei Asada, Dmitry M. Korzhnev, Irina Bezsonova, Alan D. D’Andrea

This paper identifies a PIP motif in RAD18 essential for PCNA ubiquitination and shows USP1 inhibition leads to synthetic lethality in BRCA1-deficient cells.

bioRxiv · May 10, 2026 · PreprintBiochemistry

DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation

Natália Cestari Moreno, Emilie J. Korchak, Marcela Teatin Latância, Dana A. D’Orlando, Temidayo Adegbenro, Ryan P. Barnes, Irina Bezsonova, Roger Woodgate, Nicholas William Ashton

This study shows DNA polymerase η is regulated by both mono-ubiquitination and mono-NEDDylation at the same lysine residues, with NEDDylation disrupting foci formation.

Nucleic Acids Research · Jan 28, 2026Peer-reviewedBiochemistry