Jason H. Brickner

The paper compares ChIP-seq and ChEC-seq2 methods to study yeast RNA polymerase II transcription kinetics, finding that ChEC-seq2 better captures promoter and enhancer-bound RNAPII and enables kinetic modeling.

ChEC-seq2 improves DNA cleavage specificity for mapping in vivo protein-DNA interactions by simplifying the protocol and using a new bioinformatic pipeline.

The paper identifies Crm1 as an adaptor that links transcription factors to chromatin at the nuclear pore complex, facilitating enhancer docking.

The paper identifies a mitotically heritable, RNA polymerase II-independent H3K4 dimethylation mechanism that drives transcriptional memory in budding yeast.

This study examines the 3D genome organization in diploid yeast, finding dynamic homolog proximity and environment-induced gene relocalization.