Author

Xiaolei Cai

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Duy-Thuc NguyeniD· 2 shared Erting TangiD· 2 shared Guoshuai CaoiD· 2 shared Jun HuangiD· 2 shared Nicholas W. AsbyiD· 2 shared Wenbo ZhangiD· 2 shared Aaron Esser-Khan· 1 shared Ani SolankiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Duy-Thuc NguyenORCID

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2 papers

Recent·Most cited

Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy

Erting Tang, Yifei Hu, Guoshuai Cao, Duy-Thuc Nguyen, Nicholas W. Asby, Nada S. Aboelella, Hanna A. Ruiz, Xiaolei Cai, Wenbo Zhang, Yu Qing Zhao, Lishi Xie, Xiufen Chen, Michael Russell Bishop, Peter A. Riedell, James L. LaBelle, , Jun Huang

This study shows that low-strength type I interferon signaling enhances CAR T-cell efficacy against B-cell lymphoma and leukemia without causing in vivo toxicity.

Cancer Immunology Research · May 8, 2026Peer-reviewedImmunology

Polymer-lipid hybrid nanoparticle enhances mRNA delivery and T cell-mediated immunity

Xiaolei Cai, Min Chen, Guoshuai Cao, Nicholas W. Asby, Derek Elli, Haley Gula, Vlad I. Nicolaescu, Duy-Thuc Nguyen, Xiaodan Huang, Tanushree Dangi, Ani Solanki, Sara Woessner, Wenbo Zhang, Erting Tang, Lisa R. Volpatti, , Jun Huang

This study develops a polymer-lipid hybrid nanoparticle (PLNP) to enhance mRNA delivery and T cell immunity, showing improved antigen-specific T cell responses and protection against viral variants and cancer.

bioRxiv · Jan 24, 2026 · PreprintImmunology