Kayla Kim

Sense-and-response to intracellular signaling via nucleocytoplasmic localization control of a synthetic transcription factor platform

The paper develops a synthetic biology platform using nucleocytoplasmic localization tags to enable cells to respond to intracellular signals by inducing transgene expression.

Type I and III interferons synergize with TNF to promote virally-triggered damage to the intestinal epithelium

The paper shows that IFN-β and IFN-λ, along with TNF, promote epithelial cell death in mice and human organoids, especially in those with ATG16L1 mutations, linking it to intestinal disease.