Author
University of Science and Technology of ChinaORCID 0000-0003-2154-8035Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Yinlei Hu, Bin Li, Wen Zhang, Nianping Liu, Pengfei Cai, Falai Chen, Kun Qu
WEDGE imputes gene expression values in single-cell RNA-seq datasets using biased matrix decomposition, improving clustering and correlation recovery in sparse data.
Briefings in Bioinformatics · Feb 24, 2021Peer-reviewedBioinformatics
Solveig K. Sieberts, Thanneer Malai Perumal, Minerva M. Carrasquillo, Mariet Allen, Joseph S. Reddy, Gabriel E. Hoffman, Kristen K. Dang, John N. Calley, Philip J. Ebert, James A. Eddy, Xue Wang, Anna K. Greenwood, Sara Mostafavi, Schahram Akbarian, Jaroslav M. Bendl, , Chris Gaiteri
This paper performs a large-scale eQTL meta-analysis across cerebral cortical and cerebellar brain regions, identifying distinct eQTL patterns and demonstrating improved power over existing studies.
Scientific Data · Oct 12, 2020Peer-reviewedGenetics
Chuang Guo, Bin Li, Huan Ma, Xiaofang Wang, Pengfei Cai, Qiaoni Yu, Lin Zhu, Liying Jin, Chen Jiang, Jingwen Fang, Qian Liu, Dandan Zong, Wen Zhang, Yichen Lu, Kun Li, , Kun Qu
The paper uses single-cell analysis to show that Tocilizumab reduces monocyte-driven inflammation in severe COVID-19 but does not fully suppress immune responses.
Nature Communications · Aug 6, 2020Peer-reviewedGenomics
Bin Li, Young Li, Kun Li, Lianbang Zhu, Qiaoni Yu, Pengfei Cai, Jingwen Fang, Wen Zhang, Pengcheng Du, Chen Jiang, Jun Lin, Kun Qu
APEC improves single-cell chromatin accessibility analysis by clustering cells based on accessible regions and integrates with other tools to enhance clustering accuracy and predict gene expression and regulatory elements.
Genome biology · May 12, 2020Peer-reviewedBioinformatics