The paper investigates how actin polymerization in dendritic shafts regulates the trafficking of AMPA receptor-containing vesicles during long-term potentiation.

eLife · Jul 10, 2024Peer-reviewedNeuroscience

Nanometer-Scale Imaging of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels

Hui Liu, Hong‐Gang Wang, Geoffrey S. Pitt, Zhe J. Liu

This study develops optical imaging methods to analyze subcellular localization and dynamics of voltage-gated sodium channels in neurons, revealing developmental regulation and a novel trafficking pathway.

Journal of Neuroscience · Jun 7, 2022Peer-reviewedNeuroscience

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

Ahmed S. Abdelfattah, Takashi Kawashima, Amrita Singh, Ondřej Novák, Hui Liu, Yichun Shuai, Yi-Chieh Huang, Luke Campagnola, Stephanie C. Seeman, Jianing Yu, Jihong Zheng, Jonathan B. Grimm, Ronak H. Patel, Johannes H. Friedrich, Brett D. Mensh, , Eric R. Schreiter

The paper introduces a new genetically encoded voltage indicator, Voltron, which improves brightness and photostability for extended in vivo voltage imaging in mice, zebrafish, and fruit flies.

Science · Aug 1, 2019Peer-reviewedNeuroscience

Neuron-astrocyte metabolic coupling during neuronal stimulation protects against fatty acid toxicity

Maria S. Ioannou, Jesse Jackson, Shu‐Hsien Sheu, Chi‐Lun Chang, Aubrey V. Weigel, Hui Liu, Hilda Amalia Pasolli, C. Shan Xu, Song Pang, Doreen Matthies, Harald F. Hess, Jennifer Lippincott‐Schwartz, Zhe J. Liu

The paper shows that astrocytes detoxify fatty acids from hyperactive neurons through mitochondrial oxidation, protecting neurons from toxicity.

Cell · May 1, 2019Peer-reviewedNeuroscience