Christine Brun

A quantitative interactome map reveals affinity tailored hijacking of human cellular functions by resident and pathogenic bacteria

The paper reports a large-scale quantitative interactome of human PDZ domains and bacterial PDZ-binding motifs, showing bacteria tailor effector sequences to bind with similar or higher affinity than human PBMs to hijack host functions.

BactMentha: a database of annotated bacteria-host protein interactions

BactMentha is a database of annotated bacteria-host protein interactions for human, mouse, and rat, including virulence proteins and predicted interaction interfaces.

Drosophila melanogaster miPEP8 regulates cell size through its interaction with ref(2)P/p62

This study identifies miPEP8 as a regulator of cell size in Drosophila by interacting with ref(2)P/p62 and modulating autophagy.

mimicINT: a workflow for microbe-host protein interaction inference

mimicINT identifies microbe-host protein interactions by detecting molecular mimicry elements, showing effectiveness in analyzing bacterial and viral interactions with human proteins.

A functional landscape of human microproteins

This study identifies and characterizes the functional roles of microproteins (sPEPs) in three human tissues, revealing two distinct functional groups and their regulatory roles.

Principles of chromosome organization for meiotic recombination

The paper identifies genomic elements and protein interactions that organize meiotic chromosomes for recombination.

TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks

This study shows that the TOPOVIBL-REC114 interaction is essential for the efficiency and timing of meiotic DNA double-strand breaks in mice.

Genetic architecture of natural variation of cardiac performance in flies: from flies to Humans

The paper identifies genetic networks and regulatory elements associated with cardiac performance variation in Drosophila and finds conserved genetic architecture between flies and humans.

A map of binary SARS-CoV-2 protein interactions implicates host immune regulation and ubiquitination

The paper maps binary SARS-CoV-2 protein interactions with host proteins, identifying key processes like immune signaling and ubiquitination, and suggests therapeutic targets.

Epi-MEIF, a flexible and efficient method for detection of high order epistatic interactions from complex phenotypic traits

The paper introduces epiMEIF, a method for detecting high-order epistatic interactions in GWAS data, showing its effectiveness through simulations and an application to Drosophila cardiac traits.

MetamORF: A repository of unique short Open Reading Frames identified by both experimental and computational approaches for gene-level and meta-analysis

MetamORF compiles and normalizes unique short ORFs from human and mouse genomes using experimental and computational methods, enabling new analyses of sORF functions.

The role of 3’UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization

The paper investigates 3’UTR-protein complexes in human multifunctional proteins, finding they regulate localization and multifunctionality by enabling diverse interactions.

Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4

Generation of a versatile BiFC ORFeome library for analyzing protein-protein interactions in live Drosophila

The paper introduces a multicolor BiFC library for studying protein-protein interactions in live Drosophila using Hox proteins as a case study.

Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins

The paper identifies candidate virulence proteins of Fusobacterium nucleatum that interact with human proteins involved in inflammatory bowel disease and colorectal cancer.