Author

Julien Paul Gigan

Centre National de la Recherche ScientifiqueORCID 0000-0002-3799-6310Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Angelo PilottiiD· 2 shared Béatrice NaliD· 2 shared Daniela BarrosiD· 2 shared Evelina GattiiD· 2 shared Lou Galliot· 2 shared Paulina A García-González· 2 shared Philippe PierreiD· 2 shared Rafael José ArgüelloiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Angelo PilottiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma

Julien Paul Gigan, Paulina A García-González, Angelo Pilotti, Lou Galliot, A Reynaud, Yoan Ghaffar, Felipe Flores‐Santibáñez, Sara Ghafoori, Eve Seillier, Rosario Lavignolle, Daniela Barros, Caroline Bret, Sharon Fichaux, Alexis J. Combes, Alessandro Bani, , Rafael José Argüello

SNUPR enables single-cell UPR profiling and reveals the role of IRE-1 axis in predicting bortezomib resistance in multiple myeloma.

EMBO Molecular Medicine · Jun 29, 2026Peer-reviewedCancer Biology

Induction of the ISR by AB5 subtilase cytotoxin drives IFN-I expression in pDCs via STING activation

Daniela Barros, Beatriz H. Ferreira, Paulina A García-González, Francesco Carbone, Marine Luka, Fátima Leite-Pinheiro, Mariana D. Machado, Theopisti Nikolaou, Angelo Pilotti, Emily Goguet, Paulo Antas, Andreia V. Mendes, Lichen Zhang, Marina Cresci, Lou Galliot, , Philippe Pierre

The paper shows SubAB induces IFN-I in pDCs via STING activation and UPR, highlighting a novel mechanism of immune regulation.

Proceedings of the National Academy of Sciences · May 19, 2025Peer-reviewedImmunology

Analysis of the potential of environmental Burkholderia sensu lato isolates to cause infection in a zebrafish embryo model

Julien Paul Gigan, J Boyer, Lionel Moulin, Annette Caroline Vergunst

The study uses zebrafish embryos to assess the pathogenic potential of environmental Burkholderia s.l. isolates, finding that some strains cause mortality and strong inflammation.

bioRxiv · Dec 26, 2024 · PreprintMicrobiology