Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition
Anna Misiachna, Jan Konecny, Marharyta Kolcheva, Marek Ladislav, Lukáš Prchal, Jakub Netolický, Štěpán Kortus, Petra Zahumenska, Emily Langore, Martin Novak, Katarína Hemelíková, Zuzana Heřmanová, Michaela Hrochová, Anezka Pelikanova, Jitka Odvarkova, , Martin Hořák
This paper develops a novel NMDA receptor open-channel blocker, K2060, showing improved efficacy and reversibility compared to existing drugs like memantine and dizocilpine.
Biomedicine & Pharmacotherapy · Jul 24, 2024Peer-reviewedNeuroscience