Grant M. Landwehr

The paper uses machine learning to guide cell-free expression of carbonic anhydrases, identifying variants with improved stability under high temperatures.

The paper develops a machine learning-guided cell-free platform to accelerate enzyme engineering by mapping sequence-function relationships and optimizing enzymes for multiple chemical reactions.

This study presents a cell-free biocatalytic system for converting one-carbon substrates into acetyl-CoA using a synthetic pathway called ReForm.