RNA-Encoded PGT121-LS Anti-HIV Antibody: Comprehensive Preclinical Characterization and Translational Pharmacokinetics
Felix Tolksdorf, Johannes Nelke, Robin Johannson…·Valentin Le Douce
This paper presents an RNA-encoded bNAb platform for in vivo production of PGT121-LS, showing prolonged half-life and potent neutralization in mice and non-human primates.