Esteban A. Engel

The paper tests AAV capsid variants in non-human primates to identify those with improved retrograde transport properties.

Portable therapeutic ultrasound enhanced AAV9 delivery to the brain in mice and rhesus macaques compared to systemic injection alone.

The paper maps cerebellar pathways to forebrain regions using tracing viruses and quantitative analysis, revealing homologous networks linking cerebellar areas to sensory, motor, and associative forebrain targets.

The paper compares dopaminergic and cholinergic populations in rats to determine their role in short-term memory, finding that VTA dopamine neurons have a unique causal contribution during the delay period.

The paper identifies small herpesvirus latency-associated promoters that enable long-term, pan-neuronal transgene expression in the CNS using AAV vectors.