Christine T. N. Pham

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

This study develops programmable gene circuits that deliver IL-1Ra in a circadian manner to protect cells from inflammation.

This study shows CD55 supports MZ B cell survival and regulates TLR9 signaling, with loss of CD55 leading to reduced survival and increased apoptosis in aged mice.

This paper develops a dual-responsive synthetic gene circuit that combines circadian and inflammatory signals to enable timed and enhanced therapeutic drug delivery in inflammatory arthritis.

This study delivers SOD2 mRNA via nanoparticles to mice with abdominal aortic aneurysms, reducing aneurysm expansion and rupture by enhancing antioxidant activity and modulating inflammatory pathways.

This paper develops a bioartificial implant using CRISPR-Cas9-engineered stem cells to deliver anti-cytokine drugs in response to inflammation, reducing arthritis severity in mice.