Author

Lara Pferdehirt

Washington University in St. LouisORCID 0000-0002-1968-3636Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 2

Frequent Co-Authors

Farshid GuilakiD· 3 shared Alison K. RossiD· 2 shared Christine T. N. PhamiD· 2 shared Alireza SavadipouriD· 1 shared Amanda Cimino· 1 shared Amy L. McNultyiD· 1 shared Bo ZhangiD· 1 shared Chia‐Lung WuiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersSynthetic Biology

Farshid GuilakORCID

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3 papers

Recent·Most cited

Programmable chronogenetic gene circuits for self-regulated circadian delivery of biologic drugs

Amanda Cimino, Fiona Pat, Omolabake Oyebamiji, Lara Pferdehirt, Christine T. N. Pham, Erik D. Herzog, Farshid Guilak

This study develops programmable gene circuits that deliver IL-1Ra in a circadian manner to protect cells from inflammation.

Journal of Controlled Release · Jun 18, 2025Peer-reviewedSynthetic Biology

A Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug Delivery

Yun‐Rak Choi, Kelsey H. Collins, Luke E. Springer, Lara Pferdehirt, Alison K. Ross, Chia‐Lung Wu, Franklin T. Moutos, Natalia S. Harasymowicz, Jonathan M. Brunger, Christine T. N. Pham, Farshid Guilak

This paper develops a bioartificial implant using CRISPR-Cas9-engineered stem cells to deliver anti-cytokine drugs in response to inflammation, reducing arthritis severity in mice.

Science Advances · Sep 3, 2021Peer-reviewedSynthetic Biology

A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Robert J. Nims, Lara Pferdehirt, Noelani Ho, Alireza Savadipour, Jeremiah Lorentz, Sima Sohi, Jordan G. Kassab, Alison K. Ross, Christopher J. O’Conor, Wolfgang Liedtke, Bo Zhang, Amy L. McNulty, Farshid Guilak

This paper develops a synthetic mechanogenetic gene circuit in engineered tissues that produces a therapeutic drug in response to mechanical loading.

Science Advances · Jan 27, 2021Peer-reviewedSynthetic Biology