Cam Ha T. Tran

The paper shows that astrocyte Ca2+ signaling amplifies sustained functional hyperemia in awake mice, but not brief responses, through distinct mechanisms.

The paper identifies TRPA1 channels in brain capillary endothelial cells as key initiators of neurovascular coupling by generating retrograde signals that dilate upstream arterioles.

The paper shows that intercellular electrical signaling through gap junctions coordinates vascular responses to maintain blood flow during cerebrovascular challenges.

The paper shows seizures cause prolonged microvascular constriction in mice, linked to astrocytic and vascular smooth muscle Ca2+ changes, and COX-2 dependency.