Grant Robert Gordon

A sensitive orange fluorescent calcium ion indicator for imaging neural activity

The paper introduces OCaMP, an orange fluorescent calcium indicator that improves sensitivity and performance compared to existing green and red indicators for neural imaging.

The Diversified Astrocyte Developmental Programs are Modulated by Primary Ciliary Signaling

This study shows primary cilia modulate astrocyte diversity and function through Shh signaling and intracellular balance, affecting neuronal development and behavior.

Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

The paper shows that astrocyte Ca2+ signaling amplifies sustained functional hyperemia in awake mice, but not brief responses, through distinct mechanisms.

A genetically encoded fluorescent biosensor for extracellular L-lactate

This paper develops a genetically encoded fluorescent biosensor for extracellular L-lactate and demonstrates its use in imaging in cultured mammalian cells and brain tissue.

Spatiotemporal components of sustained functional hyperemia are differentially modulated by locomotion and silenced with vascular chemogenetics

The paper investigates the spatiotemporal dynamics of functional hyperemia in awake mice during whisker stimulation, showing distinct early and late components influenced by locomotion and vascular chemogenetics.

Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex.

This study shows that obesity impairs astrocyte function in the orbitofrontal cortex, leading to synaptic deficits that are reversed by N-acetylcysteine.

The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular network

This study shows that CD2AP loss in brain endothelial cells impairs vascular function and memory in AD models, suggesting therapeutic targeting of CD2AP pathways.

Spatiotemporal chloride dynamics in hypothalamic CRHPVN neurons

This study investigates chloride dynamics in hypothalamic CRHPVN neurons, showing that KCC2 maintains Cl- setpoints but slows during stress, with differential regulation of inhibitory synapses.

Intercellular Conduction Optimizes Arterial Network Function and Conserves Blood Flow Homeostasis during Cerebrovascular Challenges

The paper shows that intercellular electrical signaling through gap junctions coordinates vascular responses to maintain blood flow during cerebrovascular challenges.

Seizures cause sustained microvascular constriction associated with astrocytic and vascular smooth muscle Ca2+ recruitment

The paper shows seizures cause prolonged microvascular constriction in mice, linked to astrocytic and vascular smooth muscle Ca2+ changes, and COX-2 dependency.