Ghanashyam D. Ghadge

The paper develops improved machine learning models to predict translation initiation sites in neurologic diseases with expanded repeats, achieving higher accuracy than previous methods.

This study uses C. elegans models to show that eIF2D is essential for RAN translation in C9orf72 expansions, and its inhibition extends lifespan and reduces disease.

The paper investigates altered expression and mislocalization of RNA-binding proteins TDP-43 and PTB in multiple sclerosis lesions and cultured oligodendrocytes, linking them to demyelination and neurodegeneration.