Author

Paola Ballesteros‐Zebadúa

Centre Hospitalier Universitaire VaudoisORCID 0000-0003-1263-2163Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Marie‐Catherine VozeniniD· 4 shared Benoît PetitiD· 3 shared Charles L. LimoliiD· 3 shared Javier Franco‐PéreziD· 3 shared Jeannette JanseniD· 3 shared Veljko GriljiD· 3 shared Olivia G.G. DraysoniD· 2 shared Aaron B. SimoniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersCancer Biology

Marie‐Catherine VozeninORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 1, 2026

✦ In-depth digest

Differential and regionally distinct molecular responses distinguish FLASH and conventional RT in a medulloblastoma model while preserving therapeutic outcomes

Michèle Knol, Javier Franco‐Pérez, Aymeric Almeida…·Paola Ballesteros‐Zebadúa

Hypo-fractionated FLASH and conventional radiotherapy (3x10 Gy) each ablated orthotopic human medulloblastoma in nude mice; FLASH evoked distinct microglial and hippocampal transcriptional programs and less neuroinflammation.

DOI 10.64898/2026.03.16.712103

mousehuman

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BiochemistrybioRxivPreprintMar 16, 2026

FLASH Radiotherapy is faster than a heartbeat: A compartmental model to illustrate the interplay between tissue oxygen perfusion and ultra-high dose rate effects.

Paola Ballesteros‐Zebadúa, Jeannette Jansen, Veljko Grilj…·Ramin Abolfath

The paper develops a compartmental model to simulate oxygen perfusion and its interaction with ultra-high dose rate radiation in FLASH Radiotherapy, showing a sigmoidal dose-rate-response curve for lipid peroxidation.

1 citation

mouseimaging

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NeurosciencebioRxivPreprintFeb 1, 2025

Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI

Jeannette Jansen, Adam Kimbler, Olivia G.G. Drayson…·Paola Ballesteros‐Zebadúa

This study uses MRI to differentiate between unirradiated mice and those exposed to conventional or FLASH radiotherapy, finding distinct brain changes after conventional but not FLASH treatment.

DOI 10.1101/2025.02.01.636061

mouseimaging

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Cancer BiologyRadiotherapy and OncologyPeer-reviewedSep 16, 2024

A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints

Olivia G.G. Drayson, Stavros Melemenidis, Nikita Katila…·Charles L. Limoli

This study evaluates the reproducibility and temporal evolution of FLASH and CONV irradiation effects on mice, showing FLASH sparing at late but not early time points.

25 citationstop 3%

mouseelectrophysiology

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