Marie‐Catherine Vozenin

Differential and regionally distinct molecular responses distinguish FLASH and conventional RT in a medulloblastoma model while preserving therapeutic outcomes

Hypo-fractionated FLASH and conventional radiotherapy (3x10 Gy) each ablated orthotopic human medulloblastoma in nude mice; FLASH evoked distinct microglial and hippocampal transcriptional programs and less neuroinflammation.

Dosimetric Characterization and Workflow Optimization of the FLASH-SARRP for Reliable Preclinical Radiobiological Studies

This paper characterizes the FLASH-SARRP irradiator and validates a QA workflow to improve dose reproducibility in preclinical FLASH experiments.

Neuroprotection following FLASH-RT may be mediated by sustained glutamate receptor AMPAR activation in CA3 neurons

This study investigates FLASH-RT's neuroprotective effects by showing sustained AMPAR activation in CA3 neurons through early transcriptional upregulation of glutamate receptor genes.

FLASH Radiotherapy is faster than a heartbeat: A compartmental model to illustrate the interplay between tissue oxygen perfusion and ultra-high dose rate effects.

The paper develops a compartmental model to simulate oxygen perfusion and its interaction with ultra-high dose rate radiation in FLASH Radiotherapy, showing a sigmoidal dose-rate-response curve for lipid peroxidation.

Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production.

This study investigates how modifying the microstructure of a CERN CLEAR-VHEE beam at the picosecond scale affects zebrafish embryo morphogenesis and hydrogen peroxide production.

Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI

This study uses MRI to differentiate between unirradiated mice and those exposed to conventional or FLASH radiotherapy, finding distinct brain changes after conventional but not FLASH treatment.

FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates

This study shows FLASH-RT and CONV-RT produce similar levels and proportions of chromosome translocations and junction structures under various oxygen conditions.